top of page

Dissolving Penis Fillers: The Hyaluronidase Procedure Explained

5 days ago

7 min read

Nuttaphon Luchaichana M.D.

1

34

Table of Contents


Hyaluronidase: The "Antidote" for Unwanted Hyaluronic Acid Fillers

For men who are dissatisfied with the results of a hyaluronic acid (HA) based penile filler, there is a reliable and effective solution. The existence of a reversal agent is the primary reason HA fillers are considered the safest choice for this procedure. This reversal agent is an enzyme called hyaluronidase.


Picture representing HA molecules

What is Hyaluronidase?

Hyaluronidase is an enzyme protein that functions as a dispersal agent. It is naturally present in the human body and is used in medicine for various purposes, such as helping the body absorb other injected medications. In the world of aesthetic medicine, it is most famous for its "off-label" use as an antidote to HA dermal fillers. It is marketed under several brand names, including Hylenex®, Vitrase®, and Amphadase®.  


How Does It Work? The Science of Reversal

The mechanism of hyaluronidase is elegant and precise. Hyaluronic acid fillers achieve their volumizing effect through long, cross-linked chains of HA molecules. Hyaluronidase works by targeting and breaking the chemical bonds (specifically, the glycosidic linkages) that hold these chains together. This process, known as hydrolysis, effectively liquefies or "dissolves" the synthetic filler, allowing the body to rapidly metabolize and clear it from the tissue. The effects are often noticeable within hours and are typically complete within 24 to 48 hours, though swelling can mask the final result for longer.  


Is It Safe? Addressing Key Concerns

The idea of injecting a "dissolving" agent can be concerning, but when performed by a medical expert, the procedure has a very high safety profile.

  • Effect on Natural Tissue: A primary concern for patients is whether the enzyme will dissolve their body's own native tissues. Hyaluronidase does break down the body's natural hyaluronic acid in the immediate treatment area. However, this effect is temporary. The human body is constantly producing its own HA, and any native HA that is broken down is naturally replenished within 24 to 48 hours. Therefore, there are no detrimental long-term effects on the skin or tissue quality.  

  • Allergic Reactions: Allergic reactions to hyaluronidase are possible but rare, with an incidence rate reported between 0.05% and 0.69%. To minimize this risk, some practitioners may perform a small patch test before the full treatment. Furthermore, modern formulations like Hylenex are created from recombinant human sources, not animal tissues, which significantly reduces the risk of an allergic response compared to older versions. The procedure should always be performed in a clinical setting equipped to handle any potential reaction.  


The Penis Filler Revision Process: A Step-by-Step Walkthrough

The marketing of HA fillers often highlights their "reversibility" as a simple "undo" button. While this is a major safety advantage, the reality is that dissolving filler is a separate medical procedure with its own costs, recovery period, and complexities. The initial injection can cause biological changes, such as inflammation or the formation of biofilm (a community of bacteria), that may not be entirely erased simply by removing the bulk of the HA filler. Clinical experience shows that dissolution can sometimes be partial, leaving residual lumps and, in some cases, still necessitating minor surgery to achieve a completely smooth result. Therefore, it is best to view this not as a simple erasure, but as a skilled medical intervention to correct a specific problem.  


Step 1: The Expert Consultation

This is the most critical phase of the revision process. A patient will meet with an expert provider, ideally a urologist or plastic surgeon specializing in this field to discuss their concerns. The provider will perform a physical examination to assess the nature of the problem, be it lumps, asymmetry, or migration. They will confirm the type of filler used and develop a personalized treatment plan. This is where goals are established: does the patient want to dissolve the filler completely and return to their baseline, or simply "micro-dissolve" a few bumps to refine the existing result?.  


Step 2: The Dissolving Procedure

Once a plan is in place, the procedure itself is relatively quick.

  • Preparation: The penis is cleaned with an antiseptic solution. A potent topical anesthetic cream is usually applied for 20-30 minutes to numb the skin surface.  

  • Injection: The hyaluronidase enzyme, which is often mixed with a local anesthetic like lidocaine for enhanced comfort, is injected using a very fine needle. The injections are made directly into and around the areas of unwanted filler. The provider may then gently massage the area to help distribute the enzyme and facilitate the mechanical breakdown of the filler.  


Step 3: Recovery and Aftercare

Proper aftercare is essential for a smooth recovery and optimal results.

  • Immediate Aftermath: Swelling, redness, and bruising at the injection sites are normal and expected. The area may temporarily look even fuller than before due to the volume of the injected fluid and the body's natural inflammatory response to the injections.  

  • Managing Side Effects: Applying a cool compress or an ice pack wrapped in a thin cloth for 10-15 minutes at a time can help reduce swelling and discomfort.  

  • Activity Restrictions: Following activity restrictions is crucial. Patients are typically advised to avoid:

    • Sexual activity, including masturbation, for at least one to two weeks, or as directed by their physician, to allow the area to heal and the filler to settle.  

    • Strenuous exercise, heavy lifting, saunas, and hot tubs for at least 24-48 hours to minimize swelling and bruising.  

  • Aftercare Protocols: The field of penile augmentation lacks universally standardized aftercare, leading to conflicting advice. Some providers may recommend wraps or compression garments , while others explicitly advise against them, stating they can cause further deformation. At Menness Clinic, patients receive clear, evidence-based protocols, such as wearing supportive underwear with the penis positioned upwards for the first week to counteract gravity and prevent migration. This expert guidance is designed to ensure the safest healing process.  


Step 4: Results and Follow-Up

While the enzyme begins working almost immediately, the final aesthetic result will not be apparent until all swelling has subsided, which can take up to two weeks. Depending on the volume and specific type of HA filler used (some are more highly cross-linked and resistant to breakdown), a patient may require more than one dissolving session to achieve their goal. Once the area is fully healed, typically after two weeks, the patient has the option to undergo a new filler treatment with an expert provider to achieve their desired girth in a more precise and aesthetically pleasing manner.  


Answering Your Key Questions About Filler Dissolving (FAQ Format)

  • Q: Is dissolving penis fillers painful?

    • A: The penis is a highly sensitive area. However, providers mitigate discomfort by using strong topical numbing creams and mixing the hyaluronidase with a local anesthetic like lidocaine. Most patients report a sharp but very brief sting with each injection, which is generally well-tolerated.  

  • Q: What is the cost of dissolving penis fillers?

    • A: The cost varies widely depending on the provider's expertise, geographic location, and the amount of hyaluronidase required for the treatment. Prices can range from $100 to $1,500. Some clinics charge per vial (e.g., $400 per vial), and multiple vials or sessions may be necessary to achieve full dissolution, increasing the total cost. It is important to note that while a reputable injector might offer this service at a reduced cost or free of charge if they performed the initial work, this is not guaranteed.  

  • Q: How soon after getting fillers can I have them dissolved?

    • A: In the absence of an emergency complication like vascular occlusion (blockage of a blood vessel), most experts recommend waiting a minimum of two weeks after the initial filler procedure. This waiting period allows the initial swelling and bruising from the augmentation to resolve, giving the provider an accurate picture of the final result before attempting a correction.  

  • Q: Will dissolving fillers affect my erections or sensitivity?

    • A: When the procedure is performed correctly by a skilled medical professional who understands the intricate anatomy of the penis, hyaluronidase injections should have no permanent impact on erectile function, sexual sensation, or fertility.  


Why Your Choice of Provider is the Most Critical Factor

The single most important variable in the success and safety of both penile augmentation and its reversal is the expertise of the provider. The complex anatomy of the penis, with its unique layers of fascia, intricate blood supply, and delicate lymphatic system, is not something that can be mastered in a weekend training course. Complications frequently arise from procedures performed by individuals with insufficient anatomical knowledge and technical skill.  

A board-certified urologist or a plastic surgeon with deep and specific experience in male genital surgery possesses the requisite understanding to perform these procedures safely. They know the precise tissue planes for injection to avoid migration and can navigate the anatomy to minimize risks. These are the specialists who are ultimately called upon to fix complications when they occur. At Menness Clinic, our team is composed of these very specialists, board-certified urologists and plastic surgeons who are leaders in the field of men's aesthetic and sexual health.


Conclusion: Reclaiming Your Confidence and Appearance

Living with an unsatisfactory result from a cosmetic procedure can be profoundly distressing. However, for those with hyaluronic acid fillers, a negative outcome is not a permanent sentence. The hyaluronidase procedure offers a safe and effective path to correction. It is a medical intervention that, in the hands of a true expert, can dissolve unwanted filler, correct aesthetic issues, and restore a natural appearance. This process allows a patient to hit the reset button and, if they choose, to pursue their aesthetic goals again, but this time with the guidance and skill of a specialist. By taking this step, it is possible to resolve the issue and reclaim the very confidence that was the original goal.  


Don't live with results that cause you distress. Take the first step toward a solution. Schedule your confidential consultation with the men's health specialists at Menness Clinic today.


If you are just beginning your research and want to understand the full range of potential issues with all types of fillers, we recommend reading our foundational guide: When Penile Fillers Go Wrong: Your Expert Guide to Correction and Reversal


Related Posts

  • Penile Girth Enlargement

  • Circumcision 

  • Focus shockwave for sexual performance

  • Testosterone Replacement Therapy

  • Sexual Health

  • Orthopedics Treatments

  • Facial Aesthetic Treatments

  • Weight Loss Management

Nuttaphon Luchaichana, M.D. ว.52558  Urology surgeon

Phongsathorn M.D. ว.45552  Orthopedics surgeon

Siwat Serirodom, M.D ว.45628  Plastic surgeon

Napat Jirattitikarntavorn, M.D ว.57946  Anti-aging & Sexual health doctor

  • Facebook
  • X
  • Instagram
  • Whatsapp
Copyright © 2025 Menness Clinic Thailand, All Rights Reserved.

Menness Wellness (เมนเนส คลินิก)
The Vue Mall, Room G6, G Flt, Charoennakhon,
Khlong San, Khlong Ton Sai, Bangkok 10600
Open Everyday 11.00 AM - 08.00 PM

bottom of page